Load in patients with acute coronary syndrome atorvastatin on percutaneous coronary intervention in patients with inflammatory response induced myocardial injury.docVIP

 PAGE \* MERGEFORMAT 16 Load in patients with acute coronary syndrome atorvastatin on percutaneous coronary intervention in patients with inflammatory response induced myocardial injury Of: Ma Hong Zhu notation Yiwang Li Chun Li Jian Gui Liujun [Abstract] [Objective] of patients with acute coronary syndrome patients undergoing percutaneous coronary intervention (PCI) loading dose given before surgery atorvastatin on inflammatory factors after Markers of myocardial damage. [Method] selected 2008 November to July 2009 in our hospital for elective coronary intervention in patients with acute coronary syndrome in 85 cases of consecutive patients were randomly divided into experimental and control groups were 42 cases and 43 cases. atorvastatin experimental group statin 20 mg / d based on 8 h before surgery and then given load of atorvastatin 80 mg, control group given atorvastatin 20 mg / d. respectively, before surgery, 6 h and 24 h after Detection of inflammatory chemokine monocyte -1 (MCP-1) and soluble CD40 ligand (SCD40L), 24 h before and after myocardial injury markers CK-MB. [Results] comparison group, MCP -1 in the before and after PCI, 6 h, 24 h no significant difference, Pgt; 0.05, SCD40L level 24 h after PCI compared with 6 h before and after surgery were significantly decreased, P values #8203;#8203;were 0.019,0.011 , CK-MB in the before and after PCI, 24 h no significant difference, Pgt; 0.05; control group comparison, MCP-1 and SCD40L in PCI preoperative and postoperative 6 h, 24 h there was no statistical difference significance, Pgt; 0.05, CK-MB levels 24 h after PCI was significantly higher than that preoperatively, P lt;0.001; experimental and control groups were compared, before and after 6 h and MCP-1 between the two groups SCD40L no difference between the experimental group after 24 h and SCD40L MCP-1 significantly decreased compared with the control group, P values #8203;#8203;were 0.028,0.036. CK-MB groups was no significant difference