伊曲康唑与氟康唑治疗马拉色菌毛囊炎成本-效果分析.pdfVIP

.816. 中国新药与临床杂志(Chin J New Drugs Clin Rem) ， 2∞6 年 11 月，第 25 卷第 11 期 [文章编号]1∞7-7669(2006)11-0816-03 伊曲康瞠与氟康瞌治疗马拉色菌毛囊炎成本-效果分析 对玉祷，邢蕴博，杨 艳，师晋萍，周建芳 (广州市皮肤病防治所，广东广州 510095) [关键词] 伊曲康哇;氟襄哇:毛囊炎:马拉色霉菌属;成本及成本分析;费用效益分析;成本-效果分 析 [摘要] 目的:评份口服伊曲康喧与氟康哇治疗马拉色菌毛囊炎的疗效及费 1有情况。方法: 160 饲马拉色 菌毛囊炎病人随机分为 2 组。伊也束哇组 85 例，子伊曲康哇鼓囊 200 mg.d-I，口服，连续 14 出氟襄哇纽75 饵，予氟康哇胶囊 150 mg.d-1 ，口服，连续 14 d o 治疗后进行成本-效果分析 c 结果:伊曲康哇组与氟康 哇组治疗后的恙有效率分另甘为 87 % (74/85) 和 83 % (62/75) 。成本-效果比 (C/E) 分到为 3.87 和 4.24，增量成本一效果比 (âC/âE) 为 -3.16 0 敏感度分析结果与参数改变前的结果基本一致。结论:伊曲 康哇治拧马拉色曹毛囊炎有较佳的成本-效果比。 [申医分类号 ] R753 .3; R978.5 [文献标iR码] A Cost-effectiveness analysis of itraconazole and fluconazole in treatment of Malassezia folliculitis 口U Yu-mei , XING Yun-bo , YANG yan , SHI Jin-ping , ZHOU Jian-fang (G皿ngzhou Municip a1 Institu化 01 Dermαtology ， Guangzhou ιUANGDONG 510095 , China) [KEY WORDSJ itraconazole; fluconazole; folliculitis; Ma1αssezia; cost and cost analysis; cost-benefit analysis; cost-effectiveness analysis [ABSTRACT] AIM: To evaluate the effectiveness and cost-effectiveness analysis of itraconazole and flucona- zole administrating orally in the treatment of Ma1ωsezia folliculitis. METHODS: One hundred and sixty patients with Ma1assezia folliculitis were randomly divided into 2 groups. Itraconazole group (85 patients) and fluconazole group (75 patients) were given orally itraconazole capsule 200 mg d- 1 and fluconazole capsule 150 mg d- 1 indi- vidually with a course of 14 d , respectively. The outcomes of the two groups were evaluatεd by cost-effectiveness analysis 站er the treatment. RESULTS: The total efficacy rates of itraconazole group and fluconazole group on Malassezia {olliculitis were 87 % (74/85) and 83 % (62/75) , with C/瓦 as 3.87 and 4.24 respectivεly. åC/ åE as -3.16 was shown in gross increase production. The result of sensitivity analysis was basically similar to the result of pre-changed paramεters. CONCLUSION: Itraconazole capsule provides the better cost-effectivεness ra- tio in compa