Matrix metalloproteinases -9 and glutamate in the cerebral infarction.doc

 PAGE \* MERGEFORMAT 12 Matrix metalloproteinases -9 and glutamate in the cerebral infarction Of: Wu Yuehua Mao-Lin Zhang Zhou community [Keywords:] Cerebral Infarction * Foundation item: Natural Science Foundation of Inner Mongolia (200208020618 Regular progress of the deterioration of acute cerebral infarction mortality and neurological deficits to increase. Ischemic cerebrovascular disease in recent years the pathophysiology of in-depth study found that: In cerebral ischemia, serum glutamate (Glu and matrix metalloproteinase - 9 (MMP-9 content anomaly [1-2], in ischemic neuronal damage and degradation play an important role in the progression, this article briefly reviewed. 1 Glu sources, distribution and physiological role Glu is not the non-essential amino acids through the blood-brain barrier, under normal circumstances, not through the blood supply of the brain, must be composed of glucose or glycolytic intermediates and other precursors by a number of synthetic chemical pathways in the brain [3]. Glu in the mammalian central nervous system are widely distributed, is the most abundant excitatory amino acid (EAA, there are a lot of projection pathways in the brain, and in the striatum, hypothalamus, hippocampus there were rich central structure containing Glu nerve cells, and plays an important role in various pathways. physiological circumstances, Glu Glu mainly in vesicles in the nerve terminals, nerve terminal depolarization, release into the synaptic cleft, acts on postsynaptic the Glu receptors involved in neuronal signaling, neurotrophic effects and neuronal plasticity, thus completing the excitatory synaptic transmission and other physiological functions. 2 MMP-9 of the sources, distribution and physiological role MMP-9 is the most important protease in the human body is one, are members of the superfamily of matrix metalloproteinase gelatinase A, also known as gelatinase B, is dependent on zinc ion metalloenzymes. MMP-9