Mechanism of post-operative pain in Progress.docVIP

 PAGE \* MERGEFORMAT 5 Mechanism of post-operative pain in Progress Various types of pain in clinical and basic research has produced many new theories, new treatments and prevention strategies and begin to apply the management of postoperative pain. It is noteworthy that, due to post-operative pain in the etiology different from the formalin injection, and capsaicin injection antigen-induced inflammatory pain, neuropathic pain is also different, so post-operative pain in response to treatment is also Unlike inflammatory pain and neuropathic pain. At present, although in some pain models there have been many new discoveries, but will these new discoveries into the management of postoperative pain has become very limited. Therefore surgical pain, as distinct from neuropathic pain and inflammatory pain, the pain of a special class to be conducted in-depth study of effective perioperative pain management is necessary. 1, sensitization and hyperalgesia tissue damage can lead to nociceptive system in the two kinds of reactions, that is, outside of Zhou Min and central sensitization [1]. Foreign Min Zhou of primary afferent fibers caused by the change, were as follows: pairs of stimulus-response threshold decreased, the increased response to suprathreshold stimulation, self-enhanced activity, receptive field (stimulus can induce afferent nerve fiber action potentials in the region ) expansion. Experimental results show that nociceptors can easily sensitized to temperature stimuli, however, mechanical stimulation of receptor sensitization (with post-operative mechanical hyperalgesia related) are difficult to verify, which has led many researchers to speculate outside the Zhou Min of possible surgery pain after mechanical hyperalgesia does not play a major role. Noxious stimulation of the input can improve the central nervous system response to pain transmission neurons, called central sensitization. For example, the damage outside the region to stimulate the spinal