Melasma New Progress.doc

 PAGE \* MERGEFORMAT 21 Melasma New Progress Melasma is also called ‘Hudie Ban’ is a common number of pigmented skin, good hair on the face, butterfly distribution was present, the cause is still not clear, and no special treatment. In recent years, the study of this disease there are many new development. 1, causes Still not fully clear. Possible factors include genetic, endocrine, pregnancy, Japan and sun light, etc., recent research has found that the incidence of this disease and micro-ecological imbalance, metabolic abnormalities, in addition, low-quality cosmetics may also be induced by one of the factors. 1. Endocrine: have shown that estrogen can stimulate the melanin cells to secrete melanin granules and progesterone can promote the transfer of melanin the body and increase the amount of melanin. Maedak and other scholars of the normal human melanoma cells were treated with pituitary hormones, (MSH (melanocyte generated hormone), ACTH, FSH (follicle-stimulating hormone) and ovarian hormones estradiol (E2), estriol (E3), progesterone ketone (P) for incubation. hatched two days later to make melanoma cells and showed increased dendritic-like changes. tests found that, in the same experimental conditions, the pituitary hormones can increase tyrosinase and tyrosinase related protein 1 ( tyrosinaserelated protein, 1 TRP1) activity, but an increase of only TRP1 ovarian hormone activity, without increasing the activity of tyrosinase. The results suggest that pituitary and ovarian hormones caused by skin pigmentation may be by stimulating epidermal melanocytes in melanin generation, and the E2 and P in the pathogenesis of melasma at work, while the adult and postmenopausal women ovarian hormones in the blood normally maintained at a high level [1]. Some studies found that patients with chloasma serum E2, E3 significantly higher level than the normal control group [2,3]. It was passed on 48 cases of female melasma patients with serum sex hormone level