Microbial Safety of the United States often high-fat diet-induced steatohepatitis effects of TNFα and PPARγ.docVIP

 PAGE \* MERGEFORMAT 2 Microbial Safety of the United States often high-fat diet-induced steatohepatitis effects of TNFα and PPARγ Author: Yu Bo, Peng Haiying, Dai Lin, left, [Abstract] Objective To investigate the TNFα and PPARγ in the formation of high-fat diet induced steatohepatitis in the role of probiotics prevention and treatment of non-alcoholic steatohepatitis in rats. Methods 40 male SD rats were randomly divided into four groups of 10 rats. Normal control group fed normal diet; model group fed high-fat feed, probiotics in the treatment group were fed high fat diet for 12 weeks after the United States often an gavage; dietary treatment group fed high fat diet for 12 weeks was later changed to normal diet feeding, 16 rats in each group were killed over the weekend, serum transaminase (ALT, AST) and tumor necrosis factor α (TNFα ) levels, hepatic malondialdehyde (MDA) content, superoxide dismutase (SOD) activity were observed in liver tissue Science changes, measured by immunohistochemical method PPARγ expression. Results In the model group of rat liver tissue MDA levels compared with normal group, (8.38 ± 1.32 μ mol / g vs 5.08 ± 0.91 μ mol / g, P