MicroRNA act on the regulation of stem cell biology.doc

 PAGE \* MERGEFORMAT 18 MicroRNA act on the regulation of stem cell biology [Abstract] Objective: With the completion of the Human Genome Project, for RNA in vivo function of increasing attention. Since 1993, the first microRNA (miRNA), lin 4, found that it has been gradually realized that there is such in vivo some non-coding RNA, their expression and regulation of genes plays an important role. studies show that there is a huge biological miRNA family, involved in regulation of growth and development of organisms and many other complex life processes, and with stem cells self-renewal and there is more closely related to the differentiation. miRNA target sites combined with fast and effective degradation of miRNA target genes or inhibit protein translation, decreased CDK, cyclin, p21, p27 and other key factors in the expression of cell cycle regulation, regulation various types of stem cell renewal and differentiation, miRNA can also determine the fate of stem cells to promote the ips. This article discusses the role of stem cells in the miRNA pathway and its regulation of the biological behavior of stem cells. [Keywords:] microRNA, stem cells, self renewal, differentiation, induced pluripotent stem cells MicroRNAs (miRNAs) are 21-25 nucleotides in length, in the post-transcriptional regulation of gene expression levels of non-coding small RNAs.miRNAs the first two members are in the developmental regulation of C.elegans found when. Since This, in almost all metazoan animals such as planaria, Drosophila, plants, mammalian genomes have been found miRNAs [1]. their major role in the miRNA, made with specificity to degrade or block its translation to regulation of development and physiological processes of plants and animals. Stem cells are a class can have multiple self-renewal and differentiation potential of early undifferentiated cells, not only during the early organogenesis of the research tools of molecular events, and has become a variety of d