Modified Ma Xing Shi Gan Decoction on asthma in rats.doc

 PAGE \* MERGEFORMAT 10 Modified Ma Xing Shi Gan Decoction on asthma in rats [Abstract] Objective: To investigate the Modified Ma Xing Shi Gan Tang (MG) on ovalbumin induced bronchial asthma in rats serum and lung tissue NO, ET-1 regulation. METHODS: The intraperitoneal injection of chicken egg protein and inactivated Bordetella pertussis, made of rat asthma model. On this basis, model mice in each group were given different drug “treatment”, 2 weeks later the rats were measured in plasma and lung tissue NO, ET-1 content. Results: model group, serum and lung tissue NO, ET-1 levels were increased, the treatment group were all decreased. The serum NO content was no significant difference compared (Pgt; 0.05), NO content in lung tissue were decreased, and model group differences were statistically significant (P lt;0.01). model group, the plasma and lung tissue ET-1 levels were significantly higher compared with the normal group, the difference was statistically significant (P lt;0.01); after drug treatment The group and model group could reduce the plasma ET-1 levels (P lt;0.01). NO levels in lung tissue and lung tissue ET-1 content significantly correlated (r = 0.689, P lt;0.01). Conclusion: reduced plasma and lung tissue NO, ET-1 synthesis and release, thus reducing airway inflammation and airway epithelial renewal, reduce airway hyperresponsiveness, asthma may be one of the mechanisms MG. [Keywords:] Modified Ma Xing Shi Gan Tang; bronchial asthma; NO; ET-1 Bronchial asthma (the asthma) by eosinophils, mast cells and lymphocytes, and other non-specific inflammatory cells in patients with chronic bronchitis. Modified Ma Xing Shi Gan Tang is a clinically effective treatment of children experience asthma prescriptions, clinical observed when the acute attack of asthma in children taking the award-good effect. The main objective of this study is to observe the plasma and lung tissue in asthmatic mouse model of nitric oxide (NO), endothelin -1 (ET-1) level