Mouse oral and inhalation acute toxicity of compound herb oil.doc

 PAGE \* MERGEFORMAT 8 Mouse oral and inhalation acute toxicity of compound herb oil Author: Zhang Yin-qing, HUANG Yong-jian, Xu Wen, Wei-Rong Li [Abstract] Objective To observe the mice gavage and inhalation of the herb oil compound after the acute toxic reactions and death. Methods and static-type mice by gavage in mice exposed to inhalation exposure dose counter to observe the mice by oral and inhalation acute toxicity of compound herb oil. Results inhalation experiment, the mice suffered from spontaneous activity reduced, lying still, lethargy and other symptoms. 3.5 h after gavage mouse died, most of them occurred within 24 h after administration. Convalescent mice show no abnormalities. Conclusion mice by oral and inhalation of the herb oil compound, its low acute toxicity. [Keywords:] compound herb oil acute toxicity in mice The Compositae Atractylodes Atractylodes Atractylodes lancea (Thumb.) DC dry roots. Spleen with dampness, expelling wind and cold-dispelling, the efficacy of eyesight. Hysteresis in the clinic for wet coke card, rheumatism, arthralgia syndrome and exogenous cold wet of relying on prima facie evidence of treatment. Compound herb oil (Fu-Fang-Cang-Shu Oil) as containing the herb, patchouli, Artemsia argyi, Shichangpu, camphor leaves, and other volatile Blumea Chinese medicine, Chinese herbal compound according to the principles of compatibility set of square made of compound preparation, which contain essential oil fragrance, with sterile bacteria, purify the air of efficiency. Gao Ying [1] with supercritical fluid extraction (SFE) technology, the oil extracted from the herb, the herb contained in the prime of approximately 15% (mass fraction). According to ‘traditional Chinese medicine approach to drug approval’ requirements, active ingredients, or parts of their effective and should reach 50%. Present, there is no compound herb oil on mice by oral and inhalation acute toxicity study reported that, therefore, the experimental obse