- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
MRN complex genes in the treatment of head and neck cancer overview
PAGE \* MERGEFORMAT 11
MRN complex genes in the treatment of head and neck cancer overview
[Keywords:] MRN complex, DNA double-strand breaks, Radiosensitivity
MRN complex is the Mre11, Rad50 and Nbs1 subunits composed of a highly conserved protein complex, is the first to recognize and signal DNA double-strand break response to child. Recent studies confirm that: it is double-strand breaks in DNA (Double Strains Breaks, DSBs repair process, plays a crucial role [1,2].
1.MRN the basic structure of complex
MRN complex in the 3 subunit protein containing multiple domains, ensuring that it is the reaction of DSBs, with architectural, structural study on the enzyme, feel and function of signal transduction [3] . MRN complex formation through the direct effect of Mre11 endonuclease will Nbs1, Rad50 and DNA bind together. Rad50 is a stable maintenance of chromosome structure proteins, enzymes containing the ATP binding box ATP (ATP binding cassette ATPase , zinc hook (Zn hook, and coiled coil (coiled coils structure. Through these structures, on both sides of bridge DNA ends, and easy of Mre11 for DNA end processing. the Nbs1 subunit N terminal contains FHA (forkhead associated domain) structure domain and BRCT (C terminal of a breast cancer susceptibility protein) domain, and its C terminal with ATM kinase (ataxia telangiectasia mutated kinase) reaction with the Mre11 interaction domain and so on. through these domains, the MRN complex to play a functional role .
2.MRN the role of the basic functions of complex
In the process of repairing DSBs, MRN complex at least three major interrelated functions: quickly identify protein DNA DSBs and the establishment of a fixed framework, DSBs start point of identification and prosecution of the cell cycle signal transduction networks, and ATM kinase by DSBs outside the establishment identification, regulate the remodeling of chromatin around DSBs. MRN complex enable homologous recombination and non-homolog
您可能关注的文档
- Most private enterprises can not continue to numb anymore!.doc
- Motherwort Leonurine in the HPLC detection of.doc
- Mother of trouble - the industry leaders how to respond to market transformation.doc
- Motherwort products in the wild and cultivated products Stachydrine Comparison of the content.doc
- Mothman Kidney Capsule Determination of icariin.doc
- Motilin receptor in rat brain regions the distribution of the.doc
- Motivate your boss.doc
- Motion Strategic Brand Management.doc
- Motion sickness in rat plasma levels of calcitonin gene-related peptide changes in.doc
- Mother to child transmission of hepatitis B blockade on the clinical observation.doc
- 2025年金融科技领域战略布局规划研究报告.docx
- 高超声速飞行器推进系统热防护材料研究与应用报告.docx
- 金融科技与区块链融合下的证券市场交易透明度优化报告.docx
- 社交媒体平台算法推荐机制与内容生态在2025年金融行业的应用与风险报告.docx
- 2025年零售门店商品销售数据分析与区域市场拓展报告.docx
- 2025年在线网络侵权纠纷解决在线争议解决(ODR)平台法律适用与纠纷处理报告.docx
- 十农业科技与乡村振兴:2025年农业科技与农村旅游融合发展路径.docx
- 2025年社交媒体算法推荐机制在言情绘画领域的挑战与内容生态优化报告.docx
- 2025年环境监测物联网技术在环保产业市场品牌本土化中的应用报告.docx
- 低空旅游产业可持续发展报告:2025年消费场景拓展与环境友好.docx
文档评论(0)