Multiple brain metastases radiotherapy and prognosis.doc

 PAGE \* MERGEFORMAT 4 Multiple brain metastases radiotherapy and prognosis Author: Yu Liu Yu-min Zhao Yanmei Wang Huankun [Abstract] Objective To investigate the multiple brain metastases radiotherapy and prognosis relationship. Methods 112 patients with multiple brain metastases were used whole-brain radiation, stereotactic radiation therapy and whole brain irradiation with stereotactic radiation therapy, analysis of different methods of radiotherapy for brain metastasis survival and mortality rates. The results of whole-brain radiation, stereotactic radiation therapy and whole brain irradiation with stereotactic radiotherapy, the median survival time were 3.8,7.8 and 8.0 months. Brain metastasis fatality rate 67.7% whole-brain irradiation, stereotactic radiation therapy group 15.7%, whole brain irradiation with stereotactic radiation therapy group 11.6%. Conclusions Stereotactic radiotherapy for brain metastasis will enable patients with less local control rate, survival period be extended. [Keywords:] Stereotactic radiotherapy; whole brain irradiation; multiple brain metastases An object and method of 1.1 Object from 1993 to 2005 our department treated 112 patients with multiple brain metastasis patients, by brain CT or MRI identified as brain metastases, the number of metastases ranged from 2 to 8. The basic situation is as follows: male 67, female 45, aged 30 to 85 years old. Among them, primary tumor 73 lung cancer cases, 26 cases of breast cancer, colon cancer, 6 cases of gastric cancer, 2 cases of malignant melanoma in 2 cases, liver in 3 patients. 1.2 treatment of patients with metastasis in accordance with the number of different radiation treatments. More than 4 metastasis use whole-brain irradiation (WBRT), 2 ~ 4 Ge metastasis use of stereotactic radiotherapy (SRS / SRT) or whole brain irradiation plus stereotactic radiation therapy (WBRT SRS / SRT). Whole-brain irradiation: 6MV  X ray DT 30 ~ 40Gy / 2 ~ 4W. Stereotactic radiosurgery (S