Nano-carbon trace of the experimental study of sentinel lymph node of gastric cancer.doc

 PAGE \* MERGEFORMAT 16 Nano-carbon trace of the experimental study of sentinel lymph node of gastric cancer Of: Chen Weidong, Tang Wenhao, Bo Zhibin [Abstract] Objective: To trace carbon nano-rabbit comparative study of sentinel lymph node of gastric cancer, gastric cancer was used in nano-carbon lay the foundation for clinical research. Methods: The rabbit gastric lesions were surrounded by subserosal injection of 99Tcm SC and nano-carbon suspension ( Kana Lin, recording two tracer to the sentinel lymph node detection (SLN number of cases, SLN number and distribution, the calculation of the two tracer SLN detection sensitivity, specificity, false negative rate and forecast regional lymph node metastasis accuracy and the SLN and non-sentinel lymph node (NSLN transfer rate. Results: Nano carbon and 99Tcm SC SLN detection rate and number, showing the distribution of SLN, SLN transfer rates were not significantly different (Pgt; 0.05. two types of tracer SLN detection sensitivity, specificity, false negative rate, accuracy was no significant difference (Pgt; 0.05. Conclusion: The nano-carbon trace results of sentinel lymph node of gastric cancer with radioactive nuclide 99Tcm SC is the same, But with the development of nano carbon tracer fast and long-lasting, non-radioactive, easy to use the advantages of alternative radionuclides for gastric cancer. [Keywords:] cancer, sentinel lymph node, nano-carbon [Abstract] Objective: To evaluate the clinical application of nano carbon in visualization of sentinel lymph node (SLN) in gastric cancer surgery.Methods: Rabbit gastric cancer model was established by transplantation of VX2 cells into the gastric serosa.Nano carbon and 99Tcm SC were injected respectively into the gastric wall in rabbit model of gastric cancer.The cases, the numbers and the distribution of SLN were documented.Then the sensibility, specificity, false negative rate and the accurate rate of local lymph node metastasis were calculated, t