Narcotic drugs genomics research.doc

 PAGE \* MERGEFORMAT 9 Narcotic drugs genomics research In this paper, the basic pharmacogenomics concepts and commonly used anesthetic drugs genomics research are reviewed. Pharmacogenomics is the study of the human genome associated with the rapid development of drugs to open up new areas of genetic research, primarily to clarify drug metabolism, drug transit and drug target gene polymorphism and drug effects, including the relationship between efficacy and toxicity subjects. Genetic polymorphism in drug-genomics research base. Drug effect genes encoding enzymes, receptors, the role of ion channels as drug targets, pharmacogenomics research is the key. Through the drug metabolism gene polymorphisms and drug effects of dynamic changes in dynamics to affect the role of narcotic drugs. Gene polymorphism effects on pharmacokinetics is mainly encoded by the corresponding drug metabolism enzymes and drug transport proteins such as the impact of changes in drug absorption, distribution, transport, metabolism and biological transformation and so on. With the narcotic drug metabolism-related enzymes among other things on cytochrome-P450 family and butyrylcholinesterase research more. Gene polymorphism major impact on pharmacodynamics is the receptor protein coding gene polymorphism to individual differences in drug sensitivity to happen. Benzodiazepine class medicine and genetic polymorphism: midazolam by CYP3A metabolism of midazolam in different individuals can have five times the removal rate differences. Diazepam metabolism by CYP2C19 and CYP2D6 genetic differences in clinical medicine can be expressed as the extension of time after the sedation. Inhalation anesthetics and genetic polymorphism: RYR1 gene mutation and the MH is closely related to, and now known to have at least 23 different RYR1 gene polymorphism and MH related. Halothane hepatitis may arise from the body in the CYP2E1 under the action of halot