Nasopharyngeal angiofibroma Research.doc

 PAGE \* MERGEFORMAT 27 Nasopharyngeal angiofibroma Research Abstract nasopharyngeal angiofibroma (juvenile nasopharyngeal angiofibroma, JNA) is the essence of vascular hamartoma (vascular hamartoma), although benign, but destruction of skull base and involving the soft tissue around the bone structure may lead to serious complications . Is now on its pathogenesis, clinical manifestations and pathological changes in the relationship between the progress in respect of the new clinical practice are reviewed. 【Key Words】 Nasopharyngeal neoplasms angiofibroma Review A1 pathogenesis Martin (1948 years) made the first sex hormone dependency theory, he considered that JNA is a lack of estrogen or testosterone caused by the relatively large, while the Dane [2] is that the JNA was caused by excessive estrogen. Schiff et al [3] that the JNA is a sex hormone imbalance, through the pituitary - gonadal axis, and improve the level of sex hormone secretion, stimulating proliferation of vascular fibrous tissue. Schiff et al [4] found that in b FGF play a role in the pathogenesis of JNA. Susan et al [5] found that APC gene / β  catenin pathway in the pathogenesis of change in the JNA play an important role. Maurice, and Milad et al [6] that the JNA is a process of embryonic development can be ectopic erectile reproductive tissues left in the nasopharynx, at puberty stimulated by male hormones produced by the growth of tumors. SchinkB, etc. [7] that the first branchial arch artery due to incomplete degradation, as well as to stimulate adolescent growth and development, making residual branchial arch artery development angiofibroma. Two clinical manifestations and pathological changes in the relationship between the Nasopharyngeal angiofibroma The main clinical manifestations are epistaxis, nasal congestion; 〖HJ2mm] tumor invaded the pterygopalatine fossa, maxillary sinus posterior wall, and away from it may cause cheek uplift; oppre