Neonatal hepatitis B vaccination effectiveness and influencing factors.docVIP

 PAGE \* MERGEFORMAT 4 Neonatal hepatitis B vaccination effectiveness and influencing factors Author: Li Jun Han Chae Chi Tea Tian MA Jing Chen Qi Shunxiang Hao Zhiyong Zhang Zhiyong CHEN Ji-Chao Zhao Hui Zhang Yanhong Wang Feng Zhang Yong Bi Shengli [Abstract] Objective To analyze the neonatal hepatitis B vaccination in long-term herd immunity effect and influencing factors. Methods Zhengding County, Township, eight pilot villages a ~ 19-year-old children and teenagers in this study. By solid phase radioimmunoassay (RIA) to detect serum HBsAg, anti  HBs and anti  HBc; using Epi Info and SAS software for statistical processing. Results 1 to 19 years after immunization HBsAg-positive rate of population immune before the 9  48% down to 1  46%, anti  HBc-positive rate also increased from immunization before 33  81% down to 5  94%, anti  HBs The positive rate of 62  13%, significantly higher than the level before immunization. 3 doses of hepatitis B vaccine immunization group of children the lowest rate of HBsAg-positive for 035%. HBsAg-positive mothers of children with hepatitis B vaccine immunization failure probability of HBsAg emerged HBsAg-negative mothers of children 33  5-fold (OR). Conclusions Neonatal hepatitis B vaccination after the herd immunity effect of good mothers carrying HBsAg and hepatitis B vaccination status of the history of the impact effect of hepatitis B vaccine a key factor. [Keywords:] Hepatitis B vaccine; long-term effects; multi-factor analysis Zhengding County, Hebei Province, since 1986 the implementation of the pilot village of neonatal hepatitis B vaccination, so far, for 19 years. In order to investigate the long-term hepatitis B vaccine and herd immunity effect and influence factors, we carried out in 2005, after hepatitis B vaccination to prevent the immune effect of the investigation. The results reported as follows. An object and methods 1  1 object (1) Material: Zhengding county in Hebei Province i