Neuroendocrine-immune network theory based on the new wind of capsule treatment of rheumatoid arthritis dose-effect relationship.doc

 PAGE \* MERGEFORMAT 14 Neuroendocrine-immune network theory based on the new wind of capsule treatment of rheumatoid arthritis dose-effect relationship [Abstract] Objective neuroendocrine immune (NEI) network perspective of Xinfeng capsule treatment of rheumatoid arthritis dose-effect relationship, to explore the mechanism of the drug and seek safer and more effective to provide experimental basis for clinical treatment. Methods to AA rats model for the study were divided into new wind Capsule (XFC) low, medium and high dose group, methotrexate (MTX) group, Tripterygium glycosides tablet (TPT) group and model group, group 30 d after treatment, using ELISA method Detection of serum 5-HT, DA, ACTH, CORT, TNF-@, IL-10 levels were statistically analyzed. Results ① XFC each treatment group, middle dose group body weight increased the most obvious, with the normal group no significant difference (Pgt; 0.05); ② XFC different levels in all treatment groups could reduce the AA serum 5-HT, ACTH, CORT, TNF-@, IL-1 levels increased (P lt;0.05 or P lt;0.01) and showed some dose-effect relationship. Conclusion XFC in the dose group in the maintenance of body weight stable growth while still effectively regulate the NEI network disorder, reflecting the traditional Chinese medicine, “rousing, overall conditioning,” the advantage is the best clinical choice. [Keywords:] rheumatoid arthritis; neuroendocrine-immune Rheumatoid arthritis (RA) is a symmetric polyarthritis as the main manifestation of chronic systemic autoimmune disease, just from the immunological point of view is difficult to explain the pathogenesis of RA and disease characteristics, in recent years, neuroendocrine-immune (neuron-endocrine -immune, NEI) network of pathways in the pathogenesis of RA more and more attention. While modern medicine first proposed the concept of neuroendocrine-immune network, but has been lacking an effective means of regulating the network, and single herb or a traditional C