New multi-acid compound toxicity POM2 90d.docVIP

 PAGE \* MERGEFORMAT 7 New multi-acid compound toxicity POM2 90d Of: Zhang, in the washing river, Juan, Liu Dongyan, Li Jing [Abstract] Objective To investigate the acid compounds in POM 2 new long-term application of toxic effects in normal rats. Methods POM 2 to 1 / 10 LD50, 1 / 50 LD50 and 1 / 100 LD50 of three doses given to rats continuously fed 90d , and continue to observe the 15d, observe the animals general condition, blood, liver and kidney function and histological changes in indicators to measure rat body weight, organ coefficient, and histopathological examination. Results Compared with control group, POM 2 each dose group of blood, blood biochemistry showed no significant change, the main organ coefficient was no significant difference in histological examination showed that the major organs of the animals are sexually transmitted diseases, drug-free rational. Conclusion The compound did not show significant side effects, no drugs after stopping delayed toxicity. [Keywords:] new acid compounds; long-term toxicity test; hematological indicators; organ coefficient POM 2 is a new acid compound, has good activity against hepatitis B virus, and its low toxicity in vitro [1]. We are new drugs based on preclinical toxicology evaluation, to explore the long-term application in normal rats toxicity to the POM 2 Effect of Anti-depth study of hepatitis B virus and the safety of future clinical applications to provide experimental basis. 1 Materials and methods 1.1 The subjects of drug experiments with drugs POM 2 by the provision of Jilin University School of Public Health, paired with distilled water, high, medium and low 3 doses (1 / 10 LD50, 1 / 50 LD50, 1 / 100 LD50, LD50 = 800mg/kg .) 1.2 Animals and grouping SD rats, male and female, body weight (200 + -20) g, by the Experimental Animal Center of Jilin University, Certificate of Conformity: scxk (Kyrgyzstan) 2003 007. 120 rats were randomly divided into POM 2 high, medium and low d