Nine made the dissolution of metformin hydrochloride tablets compare.docVIP

 PAGE \* MERGEFORMAT 7 Nine made the dissolution of metformin hydrochloride tablets compare Of: Wei Shijie, literary friends people, Yang Xiaoying, Ma Ping, Wei Xiqin [Abstract] In order to compare 9 made #8203;#8203;the dissolution of metformin hydrochloride tablets, provide a reference for clinical medicine, taking nine manufacturers (namely A, B, C, D, E, F, J, H, I) of metformin hydrochloride films, using rotating basket method, reference lt;”China Pharmacopoeiagt;” -2005 version of metformin hydrochloride tablets in the dissolution experiments, HPLC determination of metformin hydrochloride tablets to calculate the percentage of cumulative dissolution, and dissolution of the Weibull parameters of the proposed equation, and through analysis of variance between groups, group dissolution parameters were statistically analyzed. Results of different manufacturers metformin hydrochloride tablets, the dissolution provisions are in line with ChP2005 version, but its dissolution parameters m, Td and T80 was statistically significant between the (P lt;0.01). From the results point of view, F, I manufacturers dissolution of metformin hydrochloride no lag time, absorbed quickly in the body after oral administration, clinical treatment of individual attention. [Keywords:] the dissolution of metformin hydrochloride by high performance liquid chromatography Metformin hydrochloride is a biguanide hypoglycemic agents, the body due to its increased sensitivity to insulin, sulfonylurea hypoglycemic agents on the take is also effective in patients with ineffective and does not stimulate insulin secretion, does not cause low blood sugar, the price relatively low, so the wide range of clinical applications. Because metformin hydrochloride marketed more types of visits made to the intrinsic quality of metformin hydrochloride tablets for the purchase of medicines in hospitals and clinical departments to provide an objective basis for drug selection, this will be a few