Ning action Granule Gilles de la Tourette syndrome Pharmacodynamic Study.doc

 PAGE \* MERGEFORMAT 9 Ning action Granule Gilles de la Tourette syndrome Pharmacodynamic Study Author: Ang Lee Source LU Rong-Ping Lv Lili Zhang Xilin [Abstract] Objective To study the dynamic Ning Granules on the Gilles de la Tourette’s syndrome pharmacodynamics and toxicity effects. Methods Ning moving particles were observed in mice fed the activities of their own influence on the subthreshold dose of sodium pentobarbital induced sleep, the rate of impact on the drainage of morphine (APO) climbing behavior in mice, right mouse brain dopamine (DA) levels and effects on the impact of acute toxicity in mice. Results Ning moving particles high-and low-dose mice could significantly inhibit the activities of their own capabilities; high-dose synergistic subthreshold dose of sodium pentobarbital induced sleep effect; high and low doses of APO were significantly inhibited due to the small rat substantia nigra - Striatum DA function within the system to enhance the role of sustained vertical climb significantly reduced time; high doses can reduce the brain DA content, low-dose also reduced the role of brain DA content in the trend. Acute toxicity test 1 d in the same amount of rat poison to small children, 77.3 times the amount of the mice to survive well. Conclusion pharmacology permit Mingning moving particles can reduce the DA content in the brain, there is calm and antagonistic behavior of APO caused by climbing to enhance and facilitate the role of sleep; toxicology table Mingning moving particles no obvious toxicity. [Keywords:] Ning moving particle / therapeutic use; Hyperactivity Tourette Syndrome / TCM therapy; pharmacology; drug toxicity; Animals, laboratory [Abstract] Objective To study the pharmacodynamics and toxicity of Ningdong granule for Tourette syndrome (TS). Methods Ningdong granule was given to the mouse by intragastric administration.After that, observe the effect on autonomic activities of mouse, the mouse sleep rate at subthreshold dose o