Ning boost liver injury in endotoxin shock tumor necrosis factor- and nitric oxide synthase.doc

 PAGE \* MERGEFORMAT 15 Ning boost liver injury in endotoxin shock tumor necrosis factor- and nitric oxide synthase On: Zheng Xiuli, Feng Quansheng, YANG Yu Zhang Qi, Qiao Juan stomach [Abstract] Objective To observe the step-up Ning liver injury in endotoxin shock rat liver tumor necrosis factor - @ (TNF-@ and inducible nitric oxide synthase (iNOS. Methods by one intravenous injection of endotoxin (LPS10 mg / kg endotoxin shock model for replication in order to boost pre-Ning animals, and dexamethasone as a positive control, immunohistochemical determination of liver TNF-@ and iNOS expression. endotoxin shock model group, the result of serious liver damage, liver tissue TNF-@ and iNOS expression compared with the control group significantly increased (P lt;0.01, boost Ning group of liver injury compared with model group, TNF-@ and iNOS expression in model group decreased significantly (P lt; 0.01. Conclusion boost ning can reduce liver injury in endotoxic shock, its mechanism and inhibition of TNF-@ and iNOS expression. [Keywords:] boost Ning, endotoxic shock, liver damage, Shengmaisan Abstract: ObjectiveTo explore the effect of Sheng Ya Ling on TNF-@ and iNOS in liver injury rats with endotoxic shock.MethodsThe rats were injected intravenously LPS 10mg/kg to make endotoxic shock models. They were pre-treated by Sheng Ya Ling with the rats given dexamethasone as positive control group. Then observed the expression of TNF-a and iNOS were measured by immunohistochemical method.Results In the endotoxic shock model group, livers of rats were severely injured and the expression of TNF-@ and iNOS in livers were increased more significantly than that in the blank control group (P lt;0.01). The liver injury of Sheng Ya Ling group was slighter than that of model group and expression of TNF-@ and iNOS were decreased more significantly than that of model group (P lt;0.01). ConclusionSheng Ya Ling can reduce liver injury by endotoxic and its mechanism may be w