Non-small cell lung cancer MIP1 expression and dendritic cell infiltration.doc

 PAGE \* MERGEFORMAT 14 Non-small cell lung cancer MIP1 expression and dendritic cell infiltration Of: Chen Yuping, Muchuan Yong, Wenggen Long, Song Lili, Huang Jianan [Abstract] Objective: To investigate the macrophage inflammatory protein 1 (MIP 1 in non-small cell lung carcinoma with tumor invasion and the relationship between the dendritic cells. Methods: The surgical removal of the 60 cases of non-small cell lung cancer specimens were detected by immunohistochemistry chemokine receptor CCR1, CCR7 expression was detected by fluorescence in situ hybridization the expression of MIP 1. Results: (1 lung cancer cell cytoplasm and membrane expression of MIP 1, while lung cancer is detected There CCR1 and CCR7-positive infiltrating dendritic cells. (2 lung cancer CCR1, CCR7 and MIP 1 expression and clinical stage of lung cancer, lymph node metastasis, and pathological type, histological grade. have expressed MIP 1 lymph node metastasis CCR1-positive tumor cells and dendritic cells was significantly higher than those without lymph node metastasis (P lt;0.05, ~ expression of MIP 1 in patients with tumor cells and the number of CCR1-positive dendritic cells was significantly higher than that of stage ~ ( P lt;0.05. (3 lung cancer cells in the MIP 1 positive expression rate and the number of CCR1-positive dendritic cells were positively correlated, and the number of CCR7-positive dendritic cells was negatively correlated (P lt;0.05. Conclusion: MIP non-small cell lung cancer expression and clinical stage 1 lung cancer and lymph node metastasis, and tumor infiltrating dendritic cell surface molecule CCR1, CCR7 expression is closely related, suggesting that MIP 1 may affect tumor infiltrating dendritic cell development and chemotactic function and participate in lung cancer immune escape and disease progression. [Keywords:] non-small cell lung cancer, macrophage inflammatory protein 1, CCR1, CCR7 [Abstract] Objective: To explore the relationship of dendr