Notoginsenoside R1 cumulative permeation in vitro percutaneous absorption studies.doc

 PAGE \* MERGEFORMAT 10 Notoginsenoside R1 cumulative permeation in vitro percutaneous absorption studies Of: Wang Xinfang, Wang Bing, Wang Ping, Gong Yansheng, Han Li, Sun Hu, Song Yongsheng [Abstract] Objective To review the research progress in recent years notoginsenoside R1, R1 notoginsenoside described the possibility of percutaneous absorption, in order to expand its clinical applications, and provide experimental basis for the development of new formulations. METHODS The experiment testing three high performance liquid chromatography Seven saponins R1 cumulative permeation amount of transdermal absorption, the experimental results by statistical methods. notoginsenoside R1 24 h the results of the cumulative penetration amount of 0.108 8 mg · ml-1, the cumulative penetration rate of about 4.35%. Conclusion Panax R1 saponins can be absorbed through the skin, the experiments for the development of a new type of PNS R1 to lay a foundation of transdermal formulations. [Keywords:] notoginsenoside R1; percutaneous absorption; cumulative permeation Transdermal drug delivery formulations is the new non-invasive way [1], such as oral administration is not only to avoid adverse reactions may occur, reducing side effects and low toxicity, and easy to use, in recent years, the development of transdermal absorption preparation increasingly attention. Panax notoginseng saponins R1 is extracted from traditional Chinese medicine effective active substances [2], pharmacological studies have shown that cardiovascular and cerebrovascular systems PNS has a good physical activity, in recent years there have been some new Panax formulations, compared with the traditional formulation is convenient, safe, effective, and easy to carry, etc., but has yet to see the percutaneous absorption preparation of the listing. notoginsenoside R1 of this study were cumulative permeation amount of transdermal absorption for the new percutaneous absorption preparation of the resear