Normal pregnancy and pregnancy induced apoptosis in placental tissues and proliferation gene expression.doc

 PAGE \* MERGEFORMAT 10 Normal pregnancy and pregnancy induced apoptosis in placental tissues and proliferation gene expression [Abstract] Objective: To investigate the normal pregnancy and pregnancy induced hypertension (PIH) pregnancy placenta bcl-2, bax, and ki67 gene expression and their relationship. Methods: Immunohistochemistry was determined the normal early, middle and late pregnancy and 30 cases of mild, moderate and severe PIH36 cases of placenta bcl-2, bax, and ki67 expression. Results: (l) bcl-2 expression was mainly localized in the villi of the syncytial trophoblast cells (S-cells), and bax in the S-cells and cytotrophoblast cells (C-ceIIs) were positive, in the villous interstitium baX also showed positive expression, but the strength less than the trophoblast. ki67 located in C-ceIIs; (2) bcl-2 positive in the late pregnancy group was lower than in early and middle pregnancy group (P amp;lt;0.05). ki67 in normal early, middle and late pregnancy group and the control group and PIH group, mild, moderate and severe PIH group were significantly different between (P amp;lt;0.01); (3) bcl-2 and bax expression and ki67 of expression had no correlation (Pamp;gt; 0.05). Conclusion: bcl-2 and bax balance at a high level in the placental tissue is not mediated apoptosis played a leading role, but does not affect the expression of both cell proliferation. [Keywords:] placental apoptosis bcl-2 bax ki67 [Paper] Human placenta not only in the fetus - the placenta - the relationship between the mother played the role of the central axis, and the functional disorders lead to maternal and fetal pathological changes, as the progress of pregnancy, villi and trophoblast continues to mature and differentiation, has been found that many substances, including proto-oncogene product of a rational expression in the placenta Yousheng. Is characterized by the development of fetal cell groups or inhibit cell proliferation and induce apoptosis of mature and, therefore,