NShc protein function in Progress.doc

 PAGE \* MERGEFORMAT 20 NShc protein function in Progress [Keywords:] N Shc protein, apoptosis, neurotrophic factor N Shc Shc proto-oncogene is a member of the family is generally believed that only in the mature central nervous system, expressed in nerve cells play an important role in survival. N Shc peripheral nerve such as the intestinal nervous system, and some tumor cells it was also expressed, it can be involved in PI3K Akt signal transduction pathway inhibits apoptosis. Meanwhile, N Shc in tumor occurrence and development of synaptic plasticity in the hippocampus and the formation in neurodegenerative diseases such as the role of the process continues to be recognized. This neurodegenerative disease and cancer prevention and control provides a new way of thinking. N Shc is a new family of Shc is an adapter protein molecule, it is generally believed that the major neurotrophic factor signal transduction, maintenance of nerve cell survival, in the process of development of nerve cells by inhibiting apoptosis in neuronal cells. recently found that N Shc on the development of many tumors may play an important role, especially neuroblastoma and thyroid cancer (1,2). In this paper, N Shc protein function were reviewed. 1 Shc structural characteristics of the family Shc family, including ShcA, ShcB (also known as Sck / Sli and ShcC (also known as N Shc or Rai) members of the three genes, which encode 6 Shc adapter protein molecules (3). ShcA encoding three elements: p52ShcA, p46ShcA and p66ShcA, ShcB only encodes a molecule p68ShcB, ShcC encoding two proteins, namely p64 N Shc and the p52 N Shc (4 ~ 6). Shc family proteins have unique structural domains of PTB CH1 SH2, PTB and SH2 is two phosphotyrosine binding domain, and the CH1 tyrosine phosphorylation sites containing Shc protein signal output is the area, and p66ShcA and p64 ShcC in the amino-terminal region contains a CH2 (3). recently discovered family of Shc Two new members of the ShcD and