Of nitric oxide and endothelin in coronary capsule on experimental myocardial injury in rats with acute myocardial ischemia protective effect.doc

 PAGE \* MERGEFORMAT 18 Of nitric oxide and endothelin in coronary capsule on experimental myocardial injury in rats with acute myocardial ischemia protective effect 【Abstract】 Objective To investigate nitric oxide (NO) and endothelin (ET) in coronary capsule to protect the role of myocardial injury in rats. Methods 30 male Wistar rats were randomly divided into normal control group, acute myocardial ischemia myocardial injury model group and Guanxinkang capsule-treated group, 10 in each group. Experiment, rats in each group to monitor ECG, myocardial enzymes (CK, CK  MB, LDH) changes were observed in serum and myocardial tissue levels of NO and ET changes. Results Guanxinkang capsule treatment group can significantly reduce the myocardial ischemia ECG ST-T segment changes in the value of the treatment group enzymes (CK, CK  MB, LDH) levels significantly lower than model group (P lt;0. 01) ; serum and myocardial tissue was significantly higher in NO, while the serum and myocardial tissue homogenates were significantly lower in ET (all P lt;0. 05). Conclusion Guanxinkang capsule could significantly reduce the myocardial damage in acute myocardial ischemia, can improve the serum and myocardial tissue NO levels, and reduce the ET level; NO and ET may be the change in control, one of the important mechanisms of myocardial injury. Keywords: nitric oxide, endothelin Guanxinkang Capsule myocardial injury in acute myocardial ischemia Effects of Guanxinkang Capsules on Nitric Oxide and Endothelin in Myocardium Damaged Rats Induced by Acute Myocardial Ischemia Abstract: ObjectiveTo evaluate the role of nitric oxide (NO) and endothelin (ET) in the protective effect of Guanxinkang Capsules in myocardium damaged rats. Methods30 male wistar rats were randomly divided into 3 groups, control group (n = 10), acute myocardial ischemia group (n = 10) and Guanxinkang Capsules group (n = 10). During the experiment, electrocardiography and serum CK, CK