Of PNS on senescence-accelerated mouse SAMP8 brain β -amyloid precursor protein expression in.doc

 PAGE \* MERGEFORMAT 8 Of PNS on senescence-accelerated mouse SAMP8 brain β -amyloid precursor protein expression in Author: Deng-Pan Wang Jin-Sheng Wu Zhong Zhenguo Lu Liang Qu Ze-Qiang Zhang Wenyan [Abstract] Objective To investigate the Panax notoginseng saponins (PNS) on the fast-aging mice SAMP8β -amyloid precursor protein (APP) in vitro. Methods The immunohistochemical method, in randomly selected high power microscope parietal cortex and hippocampus of the mouse brain white matter around the five consecutive horizons and count five horizons the average number of APP positive cells. Results PNS can significantly reduce the rapid aging of APP-positive cells in the mouse brain. Conclusion PNS right SAMP8 APP expression was inhibited. [Keywords:] Panax notoginseng saponins rapid aging of mouse β -amyloid precursor protein immunohistochemistry Alzheimer’s disease (Alzheimer’s disease, AD) also known as senile dementia, is a primary degenerative disease of brain, for the unique central cholinergic neurons in a large number of death and loss, accompanied by neuritic plaques, the formation of neurofibrillary tangles, and a folded sheet structure containing β -amyloid protein (Amyliod-protein, Aβ ) deposition [1]. Aβ deposition leading to damage of cholinergic neurons, choline acetyltransferase (Choline Acetyltransferase, ChAT) reduction in the level and acetylcholine (Acetyl choline, Ach) neurotransmitter synthesis decreased [2]. Ach in learning, memory, and activities to play an important role. Thus, treatment of the disease, the key is looking for to reduce Aβ production and deposition of drugs. 37 to 37 perennial herbs Araliaceae Panax notoginseng (Burk) FH Chen root, traditional Chinese medicine theory is that their sexual sweet, slightly bitter flavor, temperature, go hepatogastric classics, with Huayu, bleeding, promoting blood circulation and pain of the effect. Modern pharmacological studies have shown that 37 pairs of the cardiovascular system, b