On the clinical application of fluoroquinolones.docVIP

 PAGE \* MERGEFORMAT 8 On the clinical application of fluoroquinolones [Keywords:] rational use of fluoroquinolones adverse reactions Fluoroquinolones is the second PPA introduced after the advent of fluoroquinolones. Fluoroquinolones are widely applied, bacterial resistance has emerged. Since the 80 years since the widely used in clinical. These drugs against Gram-positive bacteria much higher than the PPA effects, especially for the majority of gram-negative bacteria, including Pseudomonas aeruginosa, the majority of resistant strains more significant antimicrobial activity, more than any other class of antibacterial factors, but with the general clinical applications, adverse reactions more common. Pharmacological properties 1 Broad spectrum antibiotic, particularly against Gram-negative bacteria including Pseudomonas aeruginosa, including a strong bactericidal effect on S. aureus and S. aureus enzyme production is also a good antibacterial activity, some species of Mycobacterium tuberculosis, mycoplasma, chlamydia and There is also the role of anaerobic bacteria, bacteria and other antimicrobial agents of the medicines were no cross-resistance, good oral absorption, some varieties can be administered intravenously, the body wide distribution, high concentration of tissue fluids, up to an effective inhibitory or bactericidal levels of plasma relatively long half-life, mostly 3-7 hours. plasma protein binding rate (14% -30%), the majority of the urinary excretion and urine at high concentrations for sensitive bacteria caused by respiratory infections, urinary tract infection, prostatitis, gonorrhea, and due to a variety of gram-negative bacillus infections, bone, joint, skin and soft tissue infections, adverse reactions (5% -10%), mostly mild, common are nausea, vomiting, loss of appetite, rash, headache , vertigo. occasional twitch of psychiatric symptoms, withdrawal can be dissipated [1]. fluoroquinolones in a variety of sand is not C stars st