On the effect of estrogen on rat cardiac ganglia of vascular endothelial growth factor expression.docVIP

 PAGE \* MERGEFORMAT 7 On the effect of estrogen on rat cardiac ganglia of vascular endothelial growth factor expression Of: Zhou Jing Tian He Mingheng love Ju Cheng Guirong [Abstract] Objective: observed by immunohistochemistry of adult female rats, ovariectomized rats, after 17 beta estradiol in ovariectomized rats injected cardiac ganglia of vascular endothelial growth factor (VEGF) expression and changes. Methods: Immunohistochemical staining. Results: ① The rats cardiac ganglia exist in the expression of VEGF positive cells; ② ovariectomized rat cardiac ganglia neurons significantly reduced VEGF expression was significantly decreased (P lt;0.05). Conclusion: Expression of cardiac ganglion cells within the vascular endothelial growth factor (VEGF); estrogen may affect the cardiac ganglia VEGF. [Keywords:] vascular endothelial growth factor; cardiac ganglion; estrogen; immunohistochemistry Epidemiological data show that post-menopausal women and ovariectomized significantly higher incidence of cardiovascular disease [1], the clinical use of estrogen replacement therapy was able to reduce post-menopausal women and ovariectomized incidence of cardiovascular disease, suggesting that estrogen (estrogen E) has a protective effect on the cardiovascular system [2]. Experimental results show that estrogen can promote the development of nerve cells, regulate neurotransmitter synthesis and maintenance of nerve cell survival, and many other effects [3]. vascular endothelial growth factor (vascular endothelial growth factor, VEGF) also known as vascular permeability factor (VPF) is a molecular weight of 34 ~ 4 5kD the secreted protein. Experiments show that VEGF in addition to brain expression of vascular endothelial cells, but in neuronal cells also expressed. VEGF not only promote proliferation of endothelial cells, enabling the formation of new blood vessels and increase the role of vascular permeability, but also has a neuroprotective effect. But so far