On the combination of naloxone aminophylline treatment of apnea in premature infants with primary clinical observation (60 cases).docVIP

 PAGE \* MERGEFORMAT 9 On the combination of naloxone aminophylline treatment of apnea in premature infants with primary clinical observation (60 cases) Paper Keywords Naloxone aminophylline primary apnea in preterm infants. Abstract Objective: To observe the combined treatment of naloxone aminophylline apnea in preterm infants (AOP) of the effect. Methods: The pediatric hospital in May 2002 ~ May 2006 primary treated 60 cases of apnea in preterm infants were randomly divided into treatment group 30 cases, 30 cases of the control group. Both groups in the anti-infective support and symptomatic treatment based on the use of aminophylline injection in treatment of apnea, the first time 5mg/kg intravenous loading dose, maintenance dose 12 hours later to give 2mg/kg, every 12 hours administered a second dilution After intravenous; treatment group with the naloxone injection, the first load is 0.1mg/kg intravenously, 1 hour later, according to 0.01mg / (kg * hours), continuous intravenous administration via micro-pump, the daily total not more than 0.4mg/kg. Results: The efficacy of the treatment group significantly better than the control group, there are very significant differences between the two groups P lt;0.01. Conclusions: Naloxone treatment of aminophylline combination of apnea in premature infants more effective than aminophylline alone. Materials and methods 1 show information: May 2002 ~ May 2006, our hospital pediatric neonatal intensive care unit were treated 60 cases of AOP in preterm infants, all cases are in line with “practical neonatology” AOP standard, male 32 cases, female 28 cases, 30 ~ 35 weeks gestational age, birth weight 1200 ~ 2100g, onset time in 2 ~ 3 days after birth, 26 cases; 4 days in 22 cases, 5 ~ 6 days, 12 cases were divided into treatment group and control group, 30 cases in which treatment group , male 18 cases, female 12 cases. Control group of 30 cases, 16 males and 14 females, two groups in age, s