Oxaliplatin leucovorin and fluorouracil for the treatment of advanced gastric cancer.docVIP

 PAGE \* MERGEFORMAT 6 Oxaliplatin leucovorin and fluorouracil for the treatment of advanced gastric cancer Keywords:: advanced gastric cancer Oxaliplatin (Oxaliplatin L-oHp) are three-generation platinum anticancer drugs, for a variety of tumor strains inhibit its activity and cisplatin is similar with most of the anti-cancer drugs have additive or synergistic effect [1 , 2]. I Branch in January 2003 ~ June 2005, domestic oxaliplatin (L-OHP), plus leucovorin (Leucovorin) and 5 - fluorouracil (5-FU), to form a coalition chemotherapy of advanced gastric cancer 32 cases, achieved good effect, will now report on the results as follows. An information and 1.1 General information in January 2003 ~ June 2005 our department treated 32 patients with advanced gastric cancer patients were confirmed pathologically before treatment by the B-, X ray, CT examination, isotope scan, PET-CT confirmed the existence metastasis clinical stage were stage Ⅳ, 20 males and 12 females, aged 62 ~ 70 years old, with a median age of 64 years, 16 cases of poorly differentiated adenocarcinoma of pathology, eight cases of well differentiated adenocarcinoma, mucinous adenocarcinoma in 5 cases, signet-ring cell carcinoma of the three cases, KPS ≥ 60 points, is expected to survive “3 months, blood, liver and kidney function, ECG were normal, 12 cases were newly diagnosed, 20 cases were re-treated. 1.2 Treatment with oxaliplatin 130mg/m2, intravenous 2h, day 1; Leucovorin 300mg, intravenous 2h, No. 1 ~ 5 days; 5 - fluorouracil 750mg, intravenous 6h, No. 1 ~ 5 days; every 3 weeks for one cycle, 32 patients have received two cycles of chemotherapy. 1.3 Evaluation criteria are used in all cases CT, endoscopy and measurement of surface tumors and other methods to determine efficacy, efficacy according to WHO standards are classified into complete remission (CR), partial remission (PR), stable (SD) and progress (PD), Toxicity according to WHO toxicity gra