Partial brake on insulin sensitivity in aged rats.docVIP

 PAGE \* MERGEFORMAT 8 Partial brake on insulin sensitivity in aged rats [Abstract] Objective limb immobilization on insulin sensitivity in aged rats. Methods to old Wistar rats were randomly divided into control group and the immobilization group. Immobilization group the right hind limb cast immobilization, control group were not special treatment .3 w two groups of rats after hyperinsulinemic glucose clamp technique in normal and postoperative measurement of isolated rat right soleus muscle weight, muscle cells and muscle fiber diameter, cross-sectional area. Results of glucose input rate steady braking group, the right soleus muscle wet weight, muscle cell diameter, muscle fiber cross-sectional area were significantly lower than the control group. Conclusion Local braking can cause skeletal muscle atrophy in aged rats, and to reduce the body’s sensitivity to insulin. [Keywords:] old age, insulin sensitivity, hyperinsulinemic euglycemic clamp, brake, skeletal muscle atrophy Braking is a common means of treating trauma, to relieve pain, accelerate wound healing and rehabilitation of the body play a role. But the braking caused by a variety of complications and postoperative rehabilitation of the elderly have had a life a huge impact. This preliminary study shows that partial braking can lead to obvious skeletal muscle atrophy in aged rats (1). but the braking effect on the body is not limited to local tissues and organs, the braking effect on the body systemic. elderly are diabetes and other metabolic diseases, high risk, due to clearance of glucose in skeletal muscle is the most important body of the organization, is around the main targets of insulin resistance. Therefore, the purpose of this study is to understand the local brake on the elderly insulin sensitivity. 1 Materials and methods 1.1 Experimental animals and model 40 healthy elderly (22 + -2) month old male Wistar rats were purchased from Sichuan University Huaxi Medical Center.