Patients with chronic obstructive pulmonary disease of serum concentration of theophylline.doc

 PAGE \* MERGEFORMAT 9 Patients with chronic obstructive pulmonary disease of serum concentration of theophylline [Abstract] Objective monitoring of chronic obstructive pulmonary disease (COPD treatment in the trough blood concentration of theophylline reasonable. Methods A retrospective analysis, nearly 4 years, our hospital 78 cases of COPD patients, measured by fluorescence polarization immunoassay of serum theophylline concentration, from the plasma concentration and efficacy, adverse events and other aspects of analysis, summarized. Results 60 episodes in patients with serum theophylline concentrations of 3 ~ 10 g / ml, the effective rate was 78.3%, the incidence of adverse reactions 33.3%; 24 cases meeting the patients blood concentration of theophylline 10 ~ 15 g / ml, the effective rate was 70.8%, of adverse reactions was 54.2%; 18 cases of patients with serum theophylline concentration of 15.01 ~ 20 g / ml, the effective rate was 77.85 percent, of adverse reactions was 61.1%; 6 cases, plasma concentrations of theophylline in patients withgt; 20 g / ml, the effective rate of 83.3% of adverse reactions was 66.7%. Conclusion theophylline treatment of COPD, the blood trough concentration of control in the 3 ~ 10 g / ml, to achieve a satisfactory effect, and fewer side effects. [Keywords:] theophylline, blood trough concentration, chronic obstructive pulmonary disease Theophylline as an effective bronchodilator, has been widely used in clinical practice, the effective peak plasma concentration of 10 ~ 20 g / ml, can better control asthma attacks, and chronic obstructive pulmonary disease (COPD treatment effective blood concentration, yet there is considerable controversy, the American Thoracic Society (ATS recommended for 8 ~ 12 g / ml. In this paper, 78 patients hospitalized in our hospital in patients with COPD by theophylline serum concentration monitoring were analyzed to explore serum concentration of theophylline level and effect, the relatio