Pepsinogen determination in the diagnosis of gastric diseases.docVIP

 PAGE \* MERGEFORMAT 3 Pepsinogen determination in the diagnosis of gastric diseases Author: Ling-Xia Zhang Chuang Kung-Li Zhang Yali SONG Ying Zhang Ning-Xia Fang Pepsinogen (PG) is a precursor of pepsin can be divided into two kinds of immune activity of different sub-groups: PGI and PGII [1], from the main body of stomach mucosal cells and mucous neck cells secrete, PGII may also be antral The pyloric glands and duodenal glands (Brunner gland) secretion. When the lesions occur when the gastric mucosa, PG secretory cells involved, serum PG levels corresponding changes have taken place. Thus, changes in serum PG levels in gastric mucosa to some extent reflect the changes in serum PG levels and the ratio of change in the diagnosis of gastric lesions and the site has a certain sense [2]. 1 Materials and methods 1.1 The subjects of this study in our hospital in March 2007 -2008 year in October due to various reasons, OK endoscopy of the gastric and duodenal diseases. Selected were diagnosed via biopsy histopathology confirmed that part of the study medication within one week before the absence of exceptional history (including proton pump inhibitors, H2 receptor antagonists, etc.). Is divided into six groups: ① Normal control group: mucosa normal or showed mild non-atrophic gastritis, a total of 104 patients aged 12 -78 years, mean age 46 years; ② erosive gastritis group, a total of 106 cases, aged 18 old -78 years old, average age 42 years; ③ atrophic gastritis group, a total of 108 patients aged 12 -96 years, mean age 52 years; ④ ulcers Group: ulcer outside the other parts of the pathological changes of gastric mucosa with chronic active inflammation-based, a total of 102 cases, aged 33 -73 years, mean age 52 years; ⑤ duodenal ulcer group, a total of 108 cases, aged 14 years old -81 years old, mean age 46 years; ⑥ gastric cancer group, A total of 106 cases, aged 31 -78 years, mean age 56 years. 1.2 Methods subjects collected after 8 hours fasting ven