Phenytoin on experimental peritonitis in mice lung injury in rats.doc

 PAGE \* MERGEFORMAT 9 Phenytoin on experimental peritonitis in mice lung injury in rats Study: Fan Hongbin Li Haifeng Li Ying Li Jinlei [Abstract] Objective: To study the phenytoin on experimental peritonitis in early lung injury in rats. Methods: 18 mice were randomly divided into model group, treatment group and control group. Model induced by intraperitoneal injection of acetic acid non-specific peritonitis to observe the pathological changes in abdominal, lung tissue NO (Nitric Oxide, NO), MDA (Malondialdehyde, MDA, reduced glutathione (Glutothione, GSH content. the treatment group after experimental peritonitis induced by intraperitoneal injection Phenytoin. Result: The lung tissue NO, MDA was significantly increased, GSH content was significantly decreased. NO and MDA treatment group was significantly lower than the model group, GSH was significantly increased. CONCLUSION: The mouse peritonitis increase in lung tissue and high concentrations of NO free radicals involved in injury, phenytoin treatment of early protective effect against free radical damage. [Keywords:] peritonitis, nitric oxide, malondialdehyde, phenytoin, reduced glutathione, lung injury [ABSTRACT] Objective: To explore the mechanism of lung injury induced by experimental peritonitis and to evaluate intervention of phenytoin sodium.Methods: 18 mice were randomly divided into model group, treatment group and control group.Non specific peritonitis was induced by injecting ice acetate acid into mouse s peritoneal cavity in model group.The pathologic changes of peritoneal cavity were observed and Lung specimens were obtained to determine the level of NO, MDA and GSH.In treatment group, mice were subjected to injecting phenytoin sodium after ice acetate acid injection setting up.Results: Content of NO, MDA in model group was increased and content of GSH was decreased significantly compared with that of control group.The drug of phenytoin sodium could decrease NO and MDA content an