Phyllanthus an effective part of the total extract contrast Beagle#39;s long-term toxicity test.doc

 PAGE \* MERGEFORMAT 12 Phyllanthus an effective part of the total extract contrast Beagle#39;s long-term toxicity test 【Abstract】 Objective To observe the effective parts of Phyllanthus total extract of the long-term toxicity tests may result in toxicity to the body. Methods Phyllanthus effective parts of the total extract 470,210,90 mg / kg daily oral administration of a second; continuous administration of 45,90,180 d and withdrawal 30 d, observe the contrast grid (Beagle) dogs growth and development as well as routine hematology, blood biochemical parameters, electrocardiogram; and continuous administration of 180 d and 30 d after withdrawal of the main organs weight ratio, pathological morphology of major organs. The results of the growth and development, routine hematology, electrocardiogram had no effect. 90 mg / kg: Continuous administration of 90 d, BUN, TP, Glu l Gao obviously, T-CHO decreased; but administration of 180 d and 30 d after treatment were back to normal. 210,470 mg / kg: ALT, ALP, Glu was significantly liters Gao, TP, Alb, T-CHO were significantly decreased; liver cells in mild cloudy swelling, vacuolar degeneration. However, the above change to the toxicity in the 30 d after treatment returned to normal. Conclusion 90 mg / kg group was safe dose; 210 mg / kg or more doses of toxic doses; return to normal after treatment. Keywords: Phyllanthus extract long-term toxicity Study on the Chronic Toxicity of Total Extracts of Yexiazhu (TEY) in Beagle Dog Abstract: ObjectiveTo observe the chronic toxicity of TEY in Beagle dog.MethodsRats of three experimental groups were ig TEY at dose of 1280 mg / (kg * d), 640 mg / (kg * d) and 320 mg / (kg * d) , respectively, 6 days per week for 6 months. Rats of control group were given distilled water at the same volume. Growth of rats were observed. Indexes of hematology and blood biochemistry were measured. Ratio of viscera to body were measured and the major organs were exami