pRb2-p130 cyclinD1 and MUC1 in esophageal squamous cell carcinoma.doc

 PAGE \* MERGEFORMAT 9 pRb2/p130 cyclinD1 and MUC1 in esophageal squamous cell carcinoma Authors: Han Biao, Zhang Xian-wei, Liu Jian, JIANG Peng 【Abstract】 Objective To investigate pRb2/p130, cyclinD1 and MUC1 in esophageal squamous cell carcinoma and its significance. Methods Immunohistochemical staining of pRb2/p130, cyclinD1 and MUC1 in 16 cases of normal esophageal mucosa and 60 cases of esophageal squamous cell carcinoma of the expression level of analysis of their correlation with clinicopathological correlation between the indicators and their three. The results of esophageal squamous cell carcinoma of pRb2/p130 expression with low histological grade, TNM stage, lymph node metastasis, depth of invasion; cyclinD1 high expression of cancer differentiation, lymph node metastasis; MUC1 expression and lymph node metastasis in the high - Related; Kaplan  Meier survival analysis showed that high expression of pRb2/p130 survival rate is higher than the low expression group (P = 0.0032, Log Rank test); Cox proportional hazard model analysis showed that pRb2/p130, lymph node metastasis, cancer organizations, the degree of differentiation is esophageal squamous cell carcinoma of the independent prognostic indicators. Conclusion esophageal squamous cell carcinoma in the presence of low pRb2/p130 expression and the high cyclinD1 and MUC1 expression, promote cell growth and tumor development is the occurrence and development of esophageal cancer in the important event. Keywords: pRb2/p130 cyclinD1; MUC1 immunohistochemistry; esophageal squamous cell carcinoma Expression of pRb2/p130, cyclinD1 and MUC1 in Esophageal Squamous Cell Carcinoma Keywords:: pRb2/p130; cyclinD1; MUC1; Immunohistochemistry; Esophageal squamous cell carcinoma China is one of the world’s high incidence of esophageal cancer, the patient’s morbidity and mortality is high and the prognosis is poor, a serious threat to people’s physical and mental health. Search for