Population pharmacokinetics in pediatric clinical pharmacology of.doc

 PAGE \* MERGEFORMAT 19 Population pharmacokinetics in pediatric clinical pharmacology of [Keywords:] pediatric population pharmacokinetics of Clinical Pharmacology Children are a special population, and their various physiological indicators and adults are very different. But in clinical practice, people often refer to adult dose to guide children’s medication, which seriously threatens the health of children, individual urgent establishment of the program administration. In this regard, the population pharmacokinetics of its powerful tools. 1.1 The population pharmacokinetics Introduction Population pharmacokinetics (population pharmacokinetics, PPK) is the basic principle of classical pharmacokinetic and statistical methods of combining research groups in the process of drug in the body is studied and pharmacokinetic parameters of statistical distribution and pharmacokinetics of factors branches of science [1]. a large number of studies have shown that a patient pharmacokinetic parameters within the group there is a considerable variability. Population pharmacokinetics is the study of population dynamics characteristics, pharmacokinetics by model combined with the statistical theory, a comprehensive analysis of the interaction between drugs and the body. pharmacokinetic studies by groups to understand the specific pharmacokinetics and pharmacodynamics of the overall features, calculate the pharmacokinetic parameters of group Typical values; observe the factors on the population pharmacokinetics, pharmacodynamics and determine the influence of the size; assessment of individuals groups, and individual variability within the measurement error on the pharmacokinetics, pharmacodynamics parameters the impact [2]. Group method can quantitatively describe the variability within such groups, and covariates with patients, such as age, weight, disease status explained. Pharmacokinetic parameters, including population pharmacokinetic parameters of the gr