Progress in the discovery of auxin and.docVIP

 PAGE \* MERGEFORMAT 29 Progress in the discovery of auxin and [Abstract] growth hormone (ghrelin) and its receptor in the endocrine and metabolic regulation that has made significant progress in research. In addition to the impact on the growth hormone axis, growth hormone on the body’s regulation of multiple systems has drawn increasing attention. and its cellular and molecular mechanisms and potential clinical trial is the focus of the study. This paper describes the discovery of the system, the development and further research. [Keywords:] growth hormone, growth hormone receptor to promote the secretion of growth hormone secretion promoting factor, metabolic, cardiovascular, oncology ABSTRACT: Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor. Besides the potent GH releasing action, ghrelin influences food intake, gut motility, glucose and lipid metabolism, cardiovascular system function, cell proliferation and reproductive system. In this review, we report the discovery and research progress of ghrelin and its synthetic analogues and future directions of research in this field. Ghrelin is to promote the secretion of growth hormone receptor (growth hormone secretagogue receptor, GHS R) of the endogenous ligand, also known as auxin. It is widely distributed in many tissues and organs of the body, produce a series of biological effects. 1 Ghrelin Discovery In 1977, growth hormone releasing hormone (growth hormone releasing hormone, GHRH) has not been found in the New Orleans Medical Center a group of researchers in the enkephalin based on the chemical structure of the permutations and combinations, a set of synthetic peptide. This group of short peptides has been shown to stimulate growth hormone release, and was named for the growth hormone releasing peptide (growth hormone releasing peptide, GHRP) [1]. the next two years of study did not find within the hypothalamus contains endogenous GHRP receptor. Two years la