Pulmonary thromboembolism in patients with heparin dose and time of the initial study compliance.doc

 PAGE \* MERGEFORMAT 7 Pulmonary thromboembolism in patients with heparin dose and time of the initial study compliance [Abstract] Objective To explore 13 u / (h * kg) as a starting dose of heparin anticoagulation in patients with the PTE, when compliance with the compliance time for the maintenance dose. Methods Records of 25 cases of PTE in patients before and after the use of heparin every 6 h time APTT and plasma heparin concentration values; calculation of heparin 13 u treatment of lower starting dose for 24 h, 48 h, 72 h APTT compliance rates, compliance and stability to the APTT the time required for all patients daily heparin aggregate demand. Results averaging method calculated cumulative dose for all patients within a unit time to maintain an average of heparin (12.43 ± 2.58) u / (h * kg), 95% confidence limit interval of 11.37 ~ 13.50 u / (h * kg); regression equation derived maintenance dose of heparin, respectively (11.52 ± 2.71) u / (h * kg) and 11.01 ~ 11.36 u / (h * kg). A variety of maintenance dose, the actual maintenance dose is between 11 ~ 13 u / (h * kg) of patients within 24 h and 72 h were the highest proportion, respectively, 37% and 32%; the use of 11 ~ 13 u / (h * kg) were the first day of the maintenance dose compliance rate of 75%, the next day to 100%. All patients in the initial dose of 13 u / (h * kg) treatment and after adjustment according to Raschke scale 24 h, 48 h, 72 h cumulative APTT compliance rates were 76%, 96%, 100%; compliance time for all patients a median of 18 h, the mode was 12 h. Conclusions The PTE maintenance dose of heparin in patients with an average of between 11 ~ 13 u / (h * kg); in the initial dose of heparin 13 u / (h * kg) treatment, all patients 24 h cumulative APTT compliance rate of 76% compliance The median duration of 18 h. [Keywords:] heparin APTT anticoagulant therapy of pulmonary embolism Initial study of heparin dosage and time on APTT target in pulmonary thromboembolism LUO H