Quantitative analysis of anti-keratin antibodies in rheumatoid arthritis and for evaluation of disease.docVIP

 PAGE \* MERGEFORMAT 10 Quantitative analysis of anti-keratin antibodies in rheumatoid arthritis and for evaluation of disease Study: Hong Zhu Feng Xiuyuan Zhang Yurong Fu Gong Yi Wangyong [Abstract] Objective: To observe the anti-keratin antibodies (AKA) titer and the clinical and laboratory parameters and the hand and wrist X-ray film stages the relationship between the quantitative analysis of AKA in the diagnosis of rheumatoid arthritis (RA in clinical significance. Methods: The study sub-RA group, non-RA group were detected by indirect immunofluorescence of serum AKA, rate nephelometry assay of rheumatoid factor (RF, AKA quantitative analysis of observed clinical and laboratory titer AKA indicators and hand and wrist X-ray phases. Results: RA group AKA AKA positive titer 1:10 and 1:20 based distribution, from the clinical effects, serum dilution of 1:10 for the purpose of RA-positive diagnosis of the best point boundary value, and specificity with increasing serum dilution increased, AKA AKA positive RA patients with disease progression, the titer of the value of the hand and wrist X-ray phases, RF concentrations were positively correlated. Conclusion: RA patients AKA the distribution of quantitative analysis showed 1:10 and 1:20 titer mainly from the clinical effects, serum dilution of 1:10 for the best positive diagnosis of RA boundary value point of serum dilution The higher the specificity, the stronger. AKA titers in patients with RA disease severity and disease activity were positively correlated. [Keywords:] rheumatoid arthritis, anti-keratin antibodies, quantitative analysis Abstract Objective: To study the significance of quantitative analysis of anti-keratin antibody (AKA) in rheumatoid arthritis (RA) by observing the relationship of AKA titer with clinical manifestation, lab findings and different hand and wrist X-ray stage.Methods: AKA was detected by IIF (indirect immunofluorescence) and RF was detected by rate nephelometry in 53 R