Rabbit liver endostatin on the role of liver cancer in rats.doc

 PAGE \* MERGEFORMAT 7 Rabbit liver endostatin on the role of liver cancer in rats [Abstract] Objective To study the liver endostatin (HC) on experimental liver cancer therapeutic effect and the role of links. Methods diethylnitrosamine (DEN)-induced rat liver cancer model was established by. Pathological changes in rat liver, liver nodules and liver weight / body weight. With alpha-fetoprotein (AFP), γ -glutamyl GGT (γ -GT) and alkaline phosphatase (ALP) as an observation target. Using flow cytometry of tumor cells dynamics. The results of high-dose HC more effective than adriamycin (ADM), whose role is to link G0 ~ G1 phase arrest of cell proliferation; moderate dose of HC efficacy and ADM similar, but its role is to block part of the G2 ~ M phase cell proliferation. Conclusion This study confirmed the application of HC in vivo can inhibit the proliferation of hepatoma cells and delay the occurrence and development of liver cancer. [Keywords:] Liver endostatin; rats; liver tumor; diethylnitrosamine The effect of rabbit hepatic chalone on rat hepatocellular carcinoma [Abstract] Objective To study the therapeutic effect and protective effect of experimental hepatocellular carcinoma in rats with rabbit hepatic chalone (HC). Methods Hepatoma rats were induced by diethylnitrosamine (DEN). The changes of hepatoma nodules and ratio of liver / body weight were recorded and the alpha fetoprotein (AFP), γ -glutamyl transferase (γ -GT) and alkaline phosphatase (ALP) and the pathological changes of livers were observed.The cellular dynamic parameters were studied by flow cytometry.Results HC of high dose group was better than adriamycin (ADM) group, the protective effect might be to postpone advancement of G0-G1 phase cells.HC of appropriate dose group was the same as ADM group, and the protective effect might be to postpone advancement of G2-M phase cells . Conclusion The HC in this study could inhibit the prolifiration of hepatoma cells and delay the forming