Rat Hepatocarcinogenesis bFGF expression and significance of.docVIP

 PAGE \* MERGEFORMAT 12 Rat Hepatocarcinogenesis bFGF expression and significance of Author; Bai Xian Yong, Gu Xiuhong Liu Tong-Shen, Li Xiao Yan [Abstract] Objective To study the basic fibroblast growth factor (basic fibroblast growth factor, bFGF) in hepatocellular carcinoma occurred in the process of expression and its significance. Methods The immunohistochemical ABC method diethylnitrosamine (DEN)-induced hepatocarcinogenesis in rats during basic fibroblast growth factor expression were observed. Results DEN-induced liver cancer incidence rate was 100%. BFGF expression in normal rat liver cells were negative, inducing cancer in the first 8 weeks, hepatic lobule District near the door of a small amount of blood vessels near the liver cells showed positive expression of bFGF, and portal area shows vascular endothelial cells and fibroblasts also showed positive expression of bFGF, With the development of the process induced cancer, bFGF-positive liver cell number gradually increased to the first 18 weeks induced cancer, cancer nodules in hepatocellular carcinoma cells were most positive expression of bFGF. Conclusions bFGF with liver cancer occurrence and development of relevant. [Keywords:] bFGF; rat; liver cancer; immunohistochemistry The expression and significance of basic fibroblast growth factor (bfGF) during hepatocarcinogenesis in the rats [Abstract] Objective To investigate the expression and significance of basophilic fibroblast growth factor during hepatocarcinigenesis in the rats.Methods Hepatoma was induced in the rats by administration of diethylnitrosamine (DEN), the expression of basic fibroblast growth factor (bFGF) was detected with immunohistochemical technique.Results The incidence of hepatocarcinogenesis induced by DEN was 100%, the expression of bFGF was not detected in hepatocytes of normal rats, a few of bFGF positive hepatocytes were detected near the fibrous septums between hepatic lobules at 8th week after DEN treatment,