Removal of part of Ranvier areas on epiphyseal plate cartilage cells bcl-2 and bax expression in.docVIP

 PAGE \* MERGEFORMAT 5 Removal of part of Ranvier areas on epiphyseal plate cartilage cells bcl-2 and bax expression in Author: Zhangke Yong Cai Lin Yuan Cheng-Xia Wang Peng Chen’s Ark [Keywords:] bax Abstract: Objective: To investigate the apoptosis-related genes bax, bcl-2 in the Ranvier area after partial hepatectomy epiphyseal plate cartilage tissues. Methods: The resection of 12mm-long New Zealand white rabbits of Ranvier proximal tibia area, in the rabbits were killed after 1,4 weeks, from the immunohistochemistry and observed apoptosis-related gene bax, bcl-2 in the Ranvier area after partial hepatectomy Different-week-old rabbit proximal tibial epiphyseal cartilage tissues variations. Results: With the Ranvier area after partial hepatectomy, before the formation of osteopontin in epiphyseal cartilage of chondrocyte apoptosis was significantly lower than the control group, bone bridge formation after the rate of chondrocyte apoptosis was significantly higher. Conclusion: Ranvier area and the bone bridge on the epiphyseal plate chondrocyte apoptosis rate in a catalytic role in promoting the role of osteopontin more pronounced. Keywords:: bax; bcl-2; Ranvier area; epiphyseal plate Ranvier area involving injury often leads to horizontal and vertical epiphyseal growth plate disorders [1], can also lead to osteochondroma of the occurrence of bone tumors, etc. [2], Ranvier district’s role in bone development in more and more attention. Ranvier zone injury on the epiphyseal plate chondrocyte apoptosis-related genes bax and bcl-2 expression have any impact, at present remains unclear. Therefore, this study area after the removal of Ranvier epiphyseal plate cartilage as a research model, trying to epiphyseal cartilage of the overall understanding of bax and bcl-2 after the removal of Ranvier area epiphyseal plate cartilage cell proliferation and apoptosis in the process of expression to explore the bax and bcl-2 in the removal of Ranvier zone epiphyseal plat