Reptilase hemostatic effects of experimental study of dose-effect relationship.docVIP

 PAGE \* MERGEFORMAT 8 Reptilase hemostatic effects of experimental study of dose-effect relationship [Abstract] Objective To investigate the hemostatic Reptilase to play the role of dose-effect relationship. Approach to NIH mice and New Zealand white rabbits as experimental animals to study the different doses of Reptilase the impact on bleeding time, while exploring Reptilase of the New Zealand white rabbits FDP and the impact of FIB. Results When the dose was 0.023,0.07,0.21,0.63 ku / kg when Reptilase produced in New Zealand rabbits bleeding obvious role, but weaker than the role of 0.63ku/kg group 0.21ku/kg group, but the dose to achieve 1.90ku/kg, 5.71ku/kg has obvious anticoagulant effect; Reptilase the equivalent dose in mice bleeding time in rats also support the experimental results. At the same time Reptilase 0.023,0.07,0.21,0.63 ku / kg dose group of the New Zealand white rabbits FIB, FDP no significant impact, but 1.90ku/kg, 5.71ku/kg dose group has significantly reduced the efficacy of FIB and FDP in a marked increase in effect. Conclusion Reptilase bleeding on the role of NIH mice to produce the best dose may be 0.58 ~ 1.74 ku / kg between; Reptilase on the New Zealand rabbit to produce the best possible dose of hemostatic effect of 0.21 ~ 0.63ku/kg between dose to achieve 1.90ku/kg, 5.71ku/kg have a significant anticoagulant effect. [Keywords:] Reptilase; bleeding time; fibrin degradation products; plasma fibrinogen The dose-response relationship of Reptilase on hemostatic mechanism in rabbits and mice [Abstract] Objective To evaluate dose-response relationship of Reptilase on hemostatic mechanism in rabbits and mice.Methods The effects of different doses of Reptilase on BT, FDP and FIB were examined in animals.Results BT was significantly declined at the dose of 0.023, 0.07, 0.21, 0.63ku/kg for Reptilase, respectively, while the action of 0.21 ku / kg was significantly stronger than that of 0.63 ku / kg; when the dose reached to 1.90