Rhodiola of vascular dementia on rats behavior and hippocampal CA1 area Bcl-2 and Bax expression_0.doc

 PAGE \* MERGEFORMAT 13 Rhodiola of vascular dementia on rats behavior and hippocampal CA1 area Bcl-2 and Bax expression Of: CARDIO-/CEREBROVASCULAR Dong Ling Cao Juan Jijun Hu associated [Abstract]: Objective Rhodiola on cognitive function in vascular dementia rats and hippocampal CA1 area Bcl-2, Bax protein expression to explore the neuroprotective effect of Rhodiola. Methods of permanent bilateral common carotid artery ligation Preparation of forebrain ischemia induced by vascular dementia model to Morris water maze learning and memory in rats, by immunohistochemical detection of hippocampal CA1 area Bcl-2, Bax protein expression. results in the model compared with the control group , decreased cognitive ability (P lt;0.01), Bcl-2, Bax protein expression increased (P lt;0.01), treatment group and model group, significant improvement in cognitive ability (P lt;0.01), Bcl-2 protein expression significantly increased (P lt;0.01), Bax protein expression was significantly decreased (P lt;0.01). Conclusions of vascular dementia rats given Rhodiola, you can adjust the hippocampus by Bcl-2 and Bax protein expression, inhibition of neuronal apoptosis, protection nerve cells and promote the recovery of brain function to improve learning and memory in rats. [Keywords:] Rhodiola cognitive impairment of vascular dementia in rats, Bcl-2 Bax Abstract: Objective To study the effects of Rhodiola herb on behavior and the expression of Bcl-2 and Bax protein in hippocamps of vascular dementia rat induced by chonic cerebral ischemia. And the protective effect of Rhodiola herb was studied. Methods VD model was formed by adopting the permanent occlusion of bilateral carotid arteries in Wistar rats to produce the forebrain ischemia. Cognitive ability of rats were studied with the Morris water maze. The expression of Bcl-2 and Bax protein in the hippocampus were determined with immunohistochemical staining. Results VD model may decrease cognitive ability (P lt;0.01), inc