Rhubarb on experimental traumatic brain edema.doc

 PAGE \* MERGEFORMAT 14 Rhubarb on experimental traumatic brain edema [Abstract] Objective To study the rhubarb on cerebral edema after traumatic effects of their effects on experimental traumatic brain edema and possible mechanism of preventive effect. Methods 96 SD rats were randomly divided into 3 groups, sham operation group, model group, rhubarb treatment group. each sub-4 time points: 1,3,5,7 d, 8 for each time points. In addition to the sham group, each group copy Feeney free falling model of brain trauma . Among them, the treatment group were given after the model of rhubarb 500 mg / (kg d gavage. The rats were sacrificed at 1,3,5,7 d, were used to measure brain water content, brain tissue were observed ultrastructure and the application of western blot measurement of AQP4 expression in rats. Results after traumatic brain injury compared with model group, rhubarb group significantly reduced brain water content, through the electron microscope tips, rhubarb group astrocytes around capillaries foot processes to reduce swelling, mitochondria and other organelles intact. In addition, the model group, the trauma expression after 1 dAQP4 slightly increased, but to reach a minimum 3 d, 5 d starting from the expression of AQP4 gradually increased the expression of the first 7 dAQP4 still higher than the sham group. In the early traumatic brain injury with vasogenic brain edema in the main section 1,3 d, the expression of AQP4 Rhubarb group increased compared with model group, the protective effect of brain edema in the first 5,7 d the emergence of cytotoxic brain edema, rhubarb can inhibit the expression of AQP4 to reduce cerebral edema. Conclusion Rhubarb reduces traumatic brain edema, which may be adjusted after the traumatic brain injury in the surrounding brain tissue expression of AQP-4 to achieve. [Keywords:] Rhubarb traumatic brain edema in AQP4 Abstract: Objective This thesis aims to investigate impact of rhubarb on traumatic brain edema and s