RiCOM Experimental study on long-term toxicity Yigan Capsule.docVIP

 PAGE \* MERGEFORMAT 13 RiCOM Experimental study on long-term toxicity Yigan Capsule Keywords: RiCOM Yigan capsule;, and long-term toxicity;,, hematological indicators;,, organ coefficient of Abstract: Objective To observe the Cha Ruikang Yigan capsule in rats administered a long time may have toxic reactions to provide toxicological basis for clinical application. Methods equivalent dosage 150,50,25 man-days times 180 d by gavage in rats to observe the administration, the late recovery and withdrawal of the general condition of animals, mainly hematological, biochemical indicators of organizational changes and organ pathology. The results of various experimental animals, a view generally in good condition, body weight, organ coefficient, mainly hematological, biochemical indicators are basically consistent with the blank control group; administration of late, and recovery of high-dose animal urine analysis indicators and the blank control was not statistically differences; autopsy major organs had no obvious visible pathological changes, histological examination found no obvious pathological changes. Conclusion The long-term use goods, no significant toxicity, no drug, after withdrawal of delayed toxicity. Keywords:: RiCOM Yigan capsule; long-term toxicity; hematological indicators; organ coefficient Longterm Toxicity of Ruikang Yigan Capsule on Rats in vivo Abstract: ObjectiveTo observe the longterm toxicity of Ruikang Yigan Capsule on rats.MethodsWistar rats were given Rui Kang Yigan Capsule by gavage for 180 days, once a day, with three doses of 1.50 g / kg, 0.50 g / kg and 0.25g/kg (equal to 150,50 and 25 times of clinic dosage respectively). The animal general condition, indexes of hemotology and biochemistry, and the histopathology of the major organs were examined during both medium and end term of the treatment. Meanwhile, the condition of convalescence was observed in 2 weeks after feeding.ResultsThe general condition of t