Salvia active ingredients anti-atherosclerotic mechanism of progress_0.docVIP

 PAGE \* MERGEFORMAT 16 Salvia active ingredients anti-atherosclerotic mechanism of progress Keywords:] Salvia, pharmacological effects of Chinese medicine, atherosclerosis, review Atherosclerosis (AS) is an important cardiovascular disease pathology. AS the occurrence and development is a complex process, both from the arterial wall participate in local inflammation, but also through the blood system and play a role in lipid metabolic disorders [1]. salvia is Salvia Lamiaceae, its roots used as medicine, with blood stasis and pain, promoting blood circulation, Yang Xin Chufan, the effectiveness of cooling consumer carbuncle is a common treatment of cardiovascular diseases medicine. Its active ingredients include two major categories of fat-soluble and water-soluble, which took place two types of components in the AS with a certain role in all stages [2-3]. Danshen in mind as the exact treatment of cerebrovascular disease effect, and its role mechanism is also increasingly concerned by domestic and foreign researchers. now in recent years, progress in the study were reviewed. 1 Mechanism of fat-soluble components Salvia diterpenoid composed mainly of fat-soluble quinone compounds, including tanshinone Ⅰ A, tanshinone Ⅱ A, tanshinone Ⅱ B, cryptotanshinone, Salvia methyl, methylene quinone, more than 20 species of Salvia, which is the strong activity of tanshinone Ⅱ A is the most concentrated pharmaceutical composition mechanism. Antioxidant 1.1 Occurred in the early stages of AS, the main pathological changes are low-density lipoprotein (LDL) oxidation, macrophage uptake of the oxidized LDL and the inward migration of skin cells and eventually lead to a bubble generation of the early lipid streaks . Therefore, to effectively inhibit the oxidation of LDL in early lesions in AS important. tanshinone Ⅱ A has antioxidant properties, but the molecular structure of tanshinone Ⅱ A, it is a complete oxidation of the molecule, which has antioxidant shou