Se enzyme and Mechanisms of tumor suppressor.doc

 PAGE \* MERGEFORMAT 13 Se enzyme and Mechanisms of tumor suppressor [Keywords:] selenium enzyme inhibition of cancer Since 1817 the Swedish chemist Berzelius discovered the element selenium (Selenium, Se) so far, people have started to realize the process of biological trace element selenium in the importance of life [1]. Selenium in human tissues mainly selenium cysteine acid (Se Cys) and selenomethionine (Se Met) in the form of, or constitute a selenoprotein selenium enzymes. In this paper, the mechanism of its anticancer activity of selenium are summarized below. 1. The distribution of selenium Selenium is a semi-metallic element in the periodic table in chemistry at the fourth cycle, the sixth race of the 34th, and usually +2, 0, +4 and +6 oxidation state price exists. Se accounts for the composition of the crust 90/10 million, of which price of oxidation state +6 inorganic selenium salt is the most widely used form in [2]. As the content of selenium in the uneven distribution of the earth’s crust, in water and animals and plants are not the selenium content in food consistent with the distribution of selenium there is a clear regional difference, thus affecting the process of human intake of selenium [3]. total body Se 14 ~ 21 mg, the liver, pancreas and kidney were higher (including kidney selenium 4 times the liver Se, liver Se content of the remaining organizations, 4 times), skin and muscle were lower than the blood selenium. human daily intake of selenium in selenium content of food by: General Animal Se the amount of fishgt; meatgt; grains and vegetables (higher selenium content of garlic and mushrooms), but also by the selenium content of food selenium content of soil [4]. selenium intake there are individual differences, its absorption rates on existing forms of selenium, selenite orally 1 mg of solid absorption rate of 20% to 40%, dissolved in water absorption rate can be as high as 90% to 95%. Selenium is also affected by the absorpt