Search for genes that cause schizophrenia the strategy and progress of.docVIP

 PAGE \* MERGEFORMAT 11 Search for genes that cause schizophrenia the strategy and progress of Keywords:: Schizophrenia Many single-gene genetic diseases have been successfully positioned in the human genome, part of which has completed its positional cloning, but schizophrenia has a complex inheritance pattern of this disease, the study experienced great difficulties. In the past to the family, twin, and a foster son of a large number of epidemiological research suggests that the role of genetic factors, these genetic factors should be reflected in the DNA sequence on the expression and regulation. Because schizophrenia is a non-classical Mendelian genetics, is now being considered by several more moderate or more minor genetic effects of minor genetic. In addition, the dynamic mutation mechanism might also be related to the occurrence of schizophrenia. A linkage analysis Linkage analysis (linkage analysis) has been widely used in pathological mechanism of an unknown disease gene mapping, the aim is to find genes that cause human chromosome. Its principle is through a large number of disease-causing genes and genetic markers were isolated and analyzed for gene targeting. This method most suitable for patients we have more than one department studied, but requires that clinical diagnosis should be clear, the role of disease-causing gene has a strong effect, as well as understand the possible genetic model. The pairs of traits with complex genetic linkage analysis of schizophrenia are often likely to be a variety of factors, such as the proposed phenotype, incomplete penetrance, multiple disease-causing gene locus, epistasis, different incidence age, assortative mating, genetic environment of mutual roles, genetic model, the performance ratio and the clinical diagnosis of type error. Therefore, the linkage analysis of schizophrenia in the past has been slow. The current linkage analysis for the adoption of a new strategy is based on lineage identity (identi